Mamoru Kobayashi Selected Research

silodosin

8/2017	Alpha1A-adrenoceptor antagonist improves underactive bladder associated with diabetic cystopathy via bladder blood flow in rats.
1/2016	Silodosin, an α(1A)-Adrenoceptor Antagonist, May Ameliorate Ischemia-Induced Bladder Denervation and Detrusor Dysfunction by Improving Bladder Blood Flow.
10/2015	Effect of silodosin, a selective α(1A)-adrenoceptor antagonist, on voiding behavior and bladder blood flow in a rat model of bladder outlet obstruction.
1/2015	Effects of Silodosin, an α1A-Adrenoceptor Antagonist, and Distigmine, an Acetylcholinesterase Inhibitor, and Their Combined Effects on Impaired Voiding Function in Zucker Diabetic Fatty Rats.
6/2009	Effects of silodosin and tamsulosin on the urethra and cardiovascular system in young and old dogs with benign prostatic hyperplasia.
9/2006	A selective alpha1A-adrenoceptor antagonist inhibits detrusor overactivity in a rat model of benign prostatic hyperplasia.
3/2006	[Effects of silodosin (KMD-3213) on phenylephrine-induced increase in intraurethral pressure and blood pressure in rats--study of the selectivity for lower urinary tract].
3/2006	[Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia].
1/2006	Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for the obstructive component of benign prostatic hyperplasia.
1/2006	Cardiovascular effects of the selective alphalA-adrenoceptor antagonist silodosin (KMD-3213), a drug for the treatment of voiding dysfunction.

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Mamoru Kobayashi Research Topics

Disease

4	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 06/2009 - 01/2006
2	Heart Failure 06/2020 - 12/2018
2	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2019 - 12/2018
2	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2019 - 12/2017
2	Macular Degeneration (Age-Related Maculopathy) 08/2018 - 10/2014
2	Macular Edema 01/2018 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 07/2017 - 01/2015
2	Ischemia 01/2016 - 02/2006
2	Hypotension (Low Blood Pressure) 06/2009 - 03/2006
2	Dysuria 03/2006 - 01/2006
1	Neoplasms (Cancer) 01/2023
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2023
1	Vasculitis (Vasculitides) 05/2022
1	Hyperemia 11/2020
1	Mixed Connective Tissue Disease (MCTD) 06/2020
1	Acute Hemorrhagic Pancreatitis 06/2020
1	Pneumonia (Pneumonitis) 09/2019
1	Sepsis (Septicemia) 09/2019
1	Mycoses (Diseases, Fungus) 09/2019
1	Disease Progression 01/2019
1	Infections 01/2019
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2019
1	Thrombocytopenia (Thrombopenia) 01/2019
1	Acute Kidney Injury (Acute Renal Failure) 01/2019
1	Respiratory Insufficiency (Respiratory Failure) 12/2018
1	Wounds and Injuries (Trauma) 12/2018
1	Systemic Vasculitis 12/2018
1	Hemorrhage 12/2018
1	Takotsubo Cardiomyopathy 12/2018
1	Atrophy 08/2018
1	Retinal Vein Occlusion 01/2018
1	Glomerulonephritis 12/2017
1	Hematuria 12/2017
1	Diabetes Mellitus 08/2017
1	Constipation 07/2017
1	Hypoglycemia (Reactive Hypoglycemia) 07/2017
1	Apnea 03/2017
1	Retinal Perforations 01/2017
1	Cataract (Cataracts) 01/2017
1	Hyperphosphatemia 01/2017
1	Fibrosis (Cirrhosis) 01/2017
1	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 01/2017
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2017
1	Secondary Hyperparathyroidism 01/2017

Drug/Important Bio-Agent (IBA)

10	silodosin FDA Link 08/2017 - 01/2006
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2022 - 12/2018
3	Adrenergic Receptors (Adrenergic Receptor)IBA 10/2015 - 03/2006
2	Methylprednisolone FDA LinkGeneric 05/2022 - 09/2019
2	GlucocorticoidsIBA 01/2019 - 12/2018
2	Retinaldehyde (Retinal)IBA 08/2018 - 01/2017
2	mitiglinideIBA 07/2017 - 02/2006
2	Tamsulosin (Flomax)FDA LinkGeneric 06/2009 - 03/2006
1	ponatinibIBA 01/2023
1	Prednisolone (Predate)FDA LinkGeneric 06/2020
1	human NPPA protein (carperitide)IBA 06/2020
1	DiureticsIBA 06/2020
1	Furosemide (Lasix)FDA LinkGeneric 06/2020
1	Hemoglobins (Hemoglobin)IBA 01/2019
1	Heparin (Liquaemin)FDA LinkGeneric 01/2019
1	AlbuminsIBA 01/2019
1	calcium heparin (Calciparine)FDA Link 01/2019
1	SteroidsIBA 01/2019
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2019
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 12/2018
1	afliberceptIBA 08/2018
1	Bevacizumab (Avastin)FDA Link 01/2018
1	N-acetyltryptophanamide (NATA)IBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	Immunoglobulin G (IgG)IBA 12/2017
1	antiglomerular basement membrane antibodyIBA 12/2017
1	Glucose (Dextrose)FDA LinkGeneric 07/2017
1	mizagliflozinIBA 07/2017
1	SymportersIBA 07/2017
1	Lubiprostone FDA Link 07/2017
1	Loperamide (Imodium)FDA LinkGeneric 07/2017
1	SodiumIBA 07/2017
1	Sitagliptin Phosphate (Januvia)FDA Link 07/2017
1	Glyburide (Glibenclamide)FDA LinkGeneric 07/2017
1	Blood Glucose (Blood Sugar)IBA 07/2017
1	Niacinamide (Nicotinamide)FDA LinkGeneric 07/2017
1	Streptozocin (Streptozotocin)FDA Link 07/2017
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 07/2017
1	Dipeptidyl-Peptidase IV InhibitorsIBA 07/2017
1	Respiratory System Agents (Respiratory Stimulants)IBA 03/2017
1	Doxapram (Doxapram Hydrochloride)FDA LinkGeneric 03/2017
1	CalciumIBA 01/2017
1	Adenine FDA LinkGeneric 01/2017
1	Phosphates (Orthophosphate)IBA 01/2017
1	lanthanum carbonate (Fosrenol)FDA Link 01/2017

Therapy/Procedure

4	Therapeutics 09/2019 - 10/2014
3	Renal Dialysis (Hemodialysis) 01/2023 - 01/2019
1	Catheters 01/2019
1	Continuous Renal Replacement Therapy 01/2019
1	Critical Care (Surgical Intensive Care) 01/2019
1	Intravitreal Injections 01/2018
1	Lasers (Laser) 01/2018
1	Light Coagulation 01/2018
1	Injections 01/2018
1	Oral Administration 07/2017
1	Intraocular Lens Implantation 01/2017